PNC-27 5/10mg

PNC-27 5/10mg
£100.00

(NOT FOR HUMAN CONSUMPTION RESEARCH USE ONLY) 

PNC-27

is an experimental synthetic peptide researched for its potential to selectively target and destroy cancer cells while leaving healthy cells intact. It is a 32-amino acid chimeric peptide composed of a specific segment from the p53 tumor suppressor protein fused to a cell-penetrating leader sequence. 

 

Mechanism of Action

PNC-27 functions through a unique process known as membranolysis: 

  • Targeting: It binds to HDM-2 (human double minute 2), a protein that is overexpressed on the surface membranes of many cancer cells but is largely absent on the membranes of healthy cells.
  • Pore Formation: Upon binding to HDM-2, the peptide assembles into transmembrane pores.
  • Necrosis: These pores cause the cell membrane to leak, leading to rapid cellular necrosis (cell death).
  • Mitochondrial Disruption: Newer research indicates that once inside the cell, the peptide may also bind to and disrupt mitochondrial membranes. 

 

Clinical Research and Status

  • Research Areas: It has been studied in vitro (laboratory) and in animal models against various cancers, including pancreatic, breast, cervical, melanoma, and leukemia.
  • Regulatory Status: PNC-27 is not FDA-approved for human medical use. It is primarily available as a "research chemical" intended for laboratory use only.
  • WADA Status: It is prohibited in professional sports under the World Anti-Doping Agency's category for non-approved substances. 

 

Safety and Risks

Significant safety concerns exist due to a lack of rigorous human clinical data: 

  • Human Data: There is virtually no published data on the efficacy or safety profile of PNC-27 in humans.
  • Adverse Events: A medical case report linked experimental PNC-27 treatment to massive gastrointestinal hemorrhagein a patient receiving the therapy at an unregulated clinic.
  • FDA Warnings: The FDA has issued public warnings about PNC-27, citing potential contamination and unknown side effects. 

Warning: PNC-27 is an experimental compound. Using it outside of a controlled clinical trial is highly risky and should only be considered under the guidance of a qualified medical professional.