MOT-C 10/40mg

MOT-C 10/40mg
£25.00

(NOT FOR HUMAN CONSUMPTION RESEARCH USE ONLY) 

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)

is a 16-amino-acid peptide encoded by the mitochondrial genome, rather than nuclear DNA. Known as a "mitochondrial-derived peptide" (MDP), it acts as a metabolic hormone that regulates energy homeostasis, primarily by targeting skeletal muscle. 

 

Key Mechanisms and Effects

  • AMPK Activation: MOTS-c's primary mechanism involves activating AMP-activated protein kinase (AMPK), a master regulator of cellular energy. This process increases glucose uptake in muscles and enhances fat oxidation.
  • Exercise Mimetic: Levels of MOTS-c naturally increase in the body during and after physical exercise. It is often called an "exercise mimetic" because it can produce similar metabolic benefits to physical activity.
  • Nuclear Translocation: Under metabolic stress, MOTS-c moves from the mitochondria to the cell nucleus to regulate gene expression related to antioxidant responses and stress adaptation. 

 

Potential Research Benefits

While primarily studied in animal models, research points to several potential therapeutic applications: 

  • Metabolic Health: It has been shown to reverse diet-induced obesity and age-dependent insulin resistance in mice.
  • Physical Performance: Treatment in older mice significantly improved physical performance, suggesting it may help counter age-related physical decline.
  • Anti-Aging: Because levels naturally decline with age, restoring MOTS-c is being investigated for its ability to promote healthy aging and protect against age-related pathologies.
  • Bone and Joint Health: Emerging studies suggest it may promote bone metabolism and protect against osteoporosis. 

 

Safety and Regulatory Status

  • FDA Status: MOTS-c is not FDA-approved for human use. As of early 2026, it is classified as a substance with significant safety concerns, and its use in compounded medications is generally prohibited.
  • Doping: It is prohibited by the World Anti-Doping Agency (WADA) and is not a legitimate dietary ingredient.
  • Side Effects: Reported effects from anecdotal use include injection site reactions, fatigue, heart palpitations, and temporary blood sugar fluctuations. Long-term safety data in humans is currently non-existent.