SERMORELIN 5/10mg

SERMORELIN 5/10mg
£39.99

(NOT FOR HUMAN CONSUMPTION RESEARCH USE ONLY) 

Sermorelin (sermorelin acetate

is a synthetic growth hormone-releasing hormone (GHRH) analogue consisting of the first 29 amino acids of the naturally occurring human GHRH. It is primarily used to stimulate the pituitary gland to release the body's own growth hormone (GH). 

 

Key Functions and Mechanism

Unlike direct GH injections, sermorelin acts as a "secretagogue," signaling the body to produce its own hormones. 

  • Pituitary Stimulation: It binds to receptors in the pituitary gland, triggering a pulsatile release of growth hormone that mimics the body's natural physiological rhythm.
  • Preserving the Axis: By supporting pituitary function, it may help maintain the growth hormone neuroendocrine axis, which typically declines with age.
  • Natural Feedback: It is regulated by the body's natural feedback loops, specifically the inhibitory hormone somatostatin, which reduces the risk of overdose compared to synthetic GH. 

 

Medical Uses and Benefits

Sermorelin has been used for both diagnostic and therapeutic purposes. 

  • Growth Hormone Deficiency (GHD): It was originally FDA-approved to treat growth failure in children with idiopathic GHD and to help diagnose pituitary function.
  • Anti-Aging and Vitality: Frequently prescribed off-label for adults to combat symptoms of aging. Potential benefits include:
    • Increased lean muscle mass and tone.
    • Improved metabolism and fat loss.
    • Enhanced skin quality through increased collagen production.
    • Improved energy levels, sleep quality, and libido. 

 

Regulatory Status and Availability

  • FDA Approval: Sermorelin was approved in 1997 but was discontinued by its manufacturer (EMD Serono) in 2008 for commercial and manufacturing reasons, rather than safety concerns. It is currently listed as a "discontinued drug product" by the FDA.
  • Compounding Pharmacies: While not available as a standard commercial drug in the U.S., it can still be obtained legally via prescription through compounding pharmacies.
  • Administration: It is typically self-administered as a daily subcutaneous injection, often at bedtime, into the fatty tissue of the stomach or thigh. 

 

Common Side Effects

Sermorelin is generally well-tolerated, with most side effects being mild. 

  • Injection Site Reactions: Pain, swelling, redness, or itching at the site of injection.
  • Systemic Effects: Transient facial flushing, mild headaches, dizziness, and nausea.