NAD+ 500/1000mg

NAD+ 500/1000mg
£70.00

(NOT FOR HUMAN CONSUMPTION RESEARCH USE ONLY) 

NAD+

(Nicotinamide adenine dinucleotide) is a vital coenzyme found in every living cell, crucial for energy production, DNA repair, and cellular signaling, and is not a peptide. Its levels naturally decline with age, which is linked to various age-related health issues. 

Function and Biological Role 

NAD+ exists in two forms: NAD+(oxidized) and NADH (reduced). Its primary function is as a metabolic messenger and an electron carrier in redox reactions. 

  • Energy Metabolism: NAD+ is essential for converting food (proteins, fats, and sugars) into ATP, the cell's energy currency, through processes like glycolysis and oxidative phosphorylation

 

  • DNA Repair: It is a critical substrate for enzymes like poly(ADP-ribose) polymerases (PARPs) that are involved in repairing damaged DNA.

 

  • Sirtuin Activation: NAD+ is required to activate sirtuin proteins, which play key roles in regulating cellular homeostasis, protecting cells from age-related decay, and maintaining circadian rhythms.

 

  • Cell Signaling: It acts as a signaling molecule, linking the cell's energy status to appropriate cellular adaptations to stress. 

 

Health Benefits and Applications 

Maintaining adequate NAD+ levels is a focus of intense anti-aging research, with potential benefits observed in studies using NAD precursors or direct administration. 

 

  • Enhanced Energy and Focus: By boosting ATP production, NAD+
    supplementation may increase energy levels, stamina, and mental clarity.

 

  • Anti-Aging: Research suggests that restoring declining NAD+ levels may improve mitochondrial function and help protect against age-related conditions like cognitive decline, metabolic disease, and sarcopenia.

 

  • Neuroprotection: It has shown promise in animal models for protecting neurons from oxidative stress and is being researched for conditions like Alzheimer's and Parkinson's diseases.

 

  • Cardiovascular Health: Preclinical studies indicate that boosting NAD+
     levels can have protective effects on the heart and vascular system. 

 

Supplementation and Safety 

NAD+ can be administered directly (via IV infusions or injections) or indirectly through precursors. 

 

  • Administration Methods: Direct administration methods (injections, IVs) ensure high bioavailability. Oral supplements often use precursors like

 

  • nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), which the body converts into NAD+

 

  • Side Effects: Supplementation is generally well-tolerated when taken in recommended amounts. Potential side effects can include nausea, fatigue, headaches, diarrhea, and stomach discomfort, which are often dose-dependent. Injections may cause injection site reactions.